Pharmaniaga Morphine Sulphate Special Precautions

Morphine is not usually given preoperatively to children under 1 year of age, and it should be given with extreme care to newborn or premature infants for other conditions. The administration of opioid analgesic during labour may cause respiratory depression in the newborn infant. It should be used with extreme caution in patients with decreased respiratory reserve. It should be used with caution in patients with myasthenia gravis. Alarming and atypical effects sometimes occur in the elderly and the dosage should be reduced in elderly and debilitated patient.
It should be given with caution or in reduced doses to patients with hypothyroidism, adrenocortical insufficiency, impaired kidney or liver function, prostatic hypertrophy, shock or inflammatory or obstructive bowel disorders.
Effects on Ability to Drive and Use Machine: Morphine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a car or operating machinery. Morphine in combination with other narcotic analgesics, phenothiazines, sedative hypnotics, and alcohol have additive depressant effects.
Patients should not drive or operate machinery.